Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran
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چکیده
منابع مشابه
Permselectivity of the glomerular capillary wall to macromolecules. I. Theoretical considerations.
The transport of macromolecules across the renal glomerular capillary wall has been described theoretically using flux equations based on (a) restricted transport through small pores, and (b) the Kedem-Katchalsky formulation. The various assumptions and limitations inherent in these two approaches are discussed. To examine the coupling between macromolecular solute transport and the determinant...
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To examine the electrostatic effects of fixed negative charges on the glomerular capillary wall, polydisperse [(3)H]DEAE dextran, a polycationic form of dextran, was infused into 10 Munich-Wistar rats. Fractional clearances of DEAE ranging in radius from 18 to 44A were determined in these rats, together with direct measurements of the forces and flows governing the glomerular filtration rate of...
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Rat kidney endothelial cell morphology was examined after introducing iron colloid particles of positive or negative charge to investigate the relationship between the electric charge and permeation through the glomerular capillary. The kidneys were first perfused with Hanks’ solution through the renal arteries and then with iron colloid particles of positive or negative charge. The iron colloi...
متن کاملInfluence of molecular configuration on the passage of macromolecules across the glomerular capillary wall
The influence of molecular configuration on the filtration of macromolecules across glomerular capillary walls was examined by comparing fractional clearances of two uncharged polysaccharides of distinctly different molecular configuration in the Munich-Wistar rat. The macromolecules employed were dextran, a slightly branched polymer of glucopyranose, and ficoll, a highly cross-linked copolymer...
متن کاملAngiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney.
Studies in experimental animals and humans have documented that inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors reduces urinary protein excretion rate and retards the development of renal injury. Here we sought to investigate whether angiotensin II (All) modified the size-selective properties to macromolecules of the glomerular capillary barrier in isolate...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1975
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(75)85863-2